67 matches found
Both computational & experimental results in single neurons & small networks demonstrate that similar network function can result from quite disparate sets of neuronal & network paramaters. We show that neurons with many different kinds of ion channels can smoothly move through different mechanisms in generating their activity patterns, thus extending their dynamic range.
We examine the brain processes involved in interactive vocal behaviors, focusing on forebrain circuitry in the songbird and the rodent, and we relate these to emerging human studies that employ a range of methods to manipulate and monitor cortical areas relevant for speech.
From birth to adulthood, an animal’s nervous system undergoes considerable expansion. Through serial electron microscopy and functional imaging studies, we reveal several developmental principles that govern the structural growth and functional maturation across the wiring diagram of C. elegans.
Reproduction is governed by the coordinated secretion of hormones from the brain & pituitary. The hormones, GnRH & LH, are released in discrete "pulses", whose unique pattern is regulated by many factors. Mechanisms by which endocrine & neural signals modulate reproductive hormone pulses in normal & disease states will be discussed, focusing on findings from mouse models.
Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimer’s disease (AD); Our findings reveal that the presynaptic terminal is particularly vulnerable and represents a critical site for manifestation of initial AD etiology.