Neuroscience Program
3 matches found
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We found precise responses to orientations in mouse visual cortex in 50,000 neuron recordings. To understand neural recordings from more complex experiments, we developed an embedding algorithm called Rastermap, which qualitatively and quantitatively outperforms t-SNE and UMAP.
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As the most numerous non-neuronal cells, astrocytes tile the entire central nervous system and play important roles in regulating neural circuits and behavior. Our recent studies have revealed context-specific responses of astrocytes to various challenges that can be exploited for neurological disorders.
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Gestational exposure to environmental toxins and socioeconomic stressors are epidemiologically linked to neurodevelopmental disorders with strong male-bias, such as autism. We modeled these prenatal risk factors in mice, by co-exposing pregnant dams to an environmental pollutant and limited-resource stress, which robustly dysregulated the maternal immune system.