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Successful adaptation to changing environmental conditions depends on the ability of one's memory to flexibly guide decision processes. Possible roles for the hippocampus and lateral habenula in this critical function will be discussed, as well as their implications for our understanding of the neural mechanisms underlying disorders of behavioral flexibility/eg-depression
This seminar will present data that increasing activity of ACh inputs to the hippocampus selectively induces stress-dependent behaviors, including increased susceptibility to social stress. Our working hypothesis-ACh signaling in hippocampus may be relevant to negative encoding bias, that is, increased focus on negative events, experienced by individuals with depression.