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Biochemistry Seminar: Dr. Amanda Whipple (Harvard University, Department of Molecular and Cellular Biology), “Regulation of gene expression in the brain by imprinted non-coding RNAs"

Event Type
Seminar/Symposium
Topics
biochemistry, biological sciences, host-pathogen interactions, microbial physiology, microbiology, molecular biology, molecular evolution, protein structure, regulation of gene expression, signal trasduction
Sponsor
Dr. Auinash Kalsotra, Department of Biochemistry
Location
Zoom Meeting: https://illinois.zoom.us/ and sign in with your @illinois.edu address
Virtual
wifi event
Date
Mar 26, 2021   12:00 pm  
Speaker
Dr. Amanda Whipple, Department of Molecular and Cellular Biology, Harvard University
Contact
Sherry Unkraut
E-Mail
sunkraut@illinois.edu
Phone
217-333-2013
Views
63
Originating Calendar
Biochemistry Department Seminars

Genomic imprinting results in the preferential expression of a gene from either the maternal or paternal allele. Nearly all imprinted domains express non-coding RNAs, including long and small non-coding RNAs, in a parental biased manner. Yet the physiological functions and molecular mechanisms of these imprinted transcripts are poorly understood. With a focus on imprinted transcripts highly expressed in neurons, we seek to understand how parental gene inheritance influences gene expression in the brain through the activity of non-coding RNAs.

We have established an in vitro system that enables detection and manipulation of allele-specific expression in neurons. We are using this system to (1) delineate the neuronal networks regulated by imprinted microRNAs, (2) identify the neuronal targets of imprinted orphan small nucleolar RNAs, and (3) build a mechanistic understanding of cis regulation by imprinted long non-coding RNAs.

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