“Prism-PET: Next generation scanner for accurate quantitative PET”
Abstract: Quantitative PET is widely considered as the imaging modality of choice for precision medicine and molecularly targeted drug discovery. PET is the only candidate for in vivo quantitative study of molecular targets in oncology. PET also has a tremendous potential contribution to advance our understanding of brain’s physiological processes and can enable early detection and tracking of neuropathological development long before the onset of clinical symptoms. I will discuss recent development in PET and factors limiting much of its potential, such as poor spatial resolution and the partial volume effect. I will introduce our new breakthrough technology called the Prism-PET to mitigate these limitations and enable accurate quantitative molecular imaging via high-resolution, high sensitivity, and economical PET. Using GATE Monte Carlo simulations, I will demonstrate the high precision of our Prism-PET scanner for imaging and quantifying molecular targets in the monoaminergic nuclei as shown from reconstructed images of 5-HT1A receptors, which are abundant in the dorsal raphe nucleus, and norepinephrine transporters, which are highly concentrated in the bilateral locus coeruleus. We have also constructed a prototype Prism-PET brain scanner with a conformal decagon geometry and I will present experimental results obtained from an ultra-micro hot spot phantom filled with F18 showing successful reconstruction of 1.35 mm regions across the entire transaxial field-of-view. Finally, I will present our future development plan of a prototype human scanner and translation of Prism-PET to the clinical setting.
Bio: Dr. Amir H. Goldan is an assistant professor of Radiology at Stony Brook University in Long Island, New York, where he is working on the development of medical imaging detectors and systems for positron emission tomography (PET) and photon counting x-ray imaging. Dr. Goldan received his Ph.D. in electrical and computer engineering from the University of Waterloo, CANADA in 2012. During his Ph.D. studies, he introduced the novel concept of unipolar time-differential charge sensing in low-mobility non-crystalline solid-state radiation detectors, a feature that enables them to achieve temporal performance similar to their high-mobility crystalline counterparts. Dr. Goldan is the inventor of Prism-PET technology which enables the development of next generation PET scanners with high-resolution and high sensitivity while making PET more economical. This concept won the best mini-oral/poster award at the 2021 IEEE NSS-MIC conference. Dr. Goldan’s federal research funding to date exceeds $6M and he currently is a PI on 4 active federal grants: two NIH R01s, one NIH R21 Trailblazer, and one NSF grant.