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MCB RNA Faculty Search Seminar: Dr. Keith Gagnon (SIU-C), “Making RNA-Guided Genomic Medicines Better with Biochemistry”

Event Type
Seminar/Symposium
Sponsor
Department of Biochemistry (HOST: Dr. Auinash Kalsotra)
Location
Charles G. Miller Auditorium, B102 Chemical and Life Sciences Laboratory
Date
Feb 9, 2023   2:00 pm  
Speaker
Dr. Keith Gagnon
Contact
Cara Day
E-Mail
caraday@illinois.edu
Phone
217-333-2013
Views
73
Originating Calendar
Biochemistry Department Seminars

*** NOTE: Time & Date is THURSDAY, FEB. 9th @ 2:00 PM ***

Genetic disorders are a final frontier in human disease and medicine. CRISPR-Cas systems represent the most promising therapeutic candidates in development for genomic medicines that can correct genetic mutations. Despite their promise, they are controversial and challenging to develop due to the danger of unanticipated and irreversible changes to a patient’s genome. Their controllability, safety, and – as rather large biologics – deliverability, stand as remaining barriers to their eventual success. This seminar will discuss progress toward full chemical modification of CRISPR-Cas9 and CRISPR-Cas12a guide RNAs for better tunability and deliverability as well as development of novel inhibitors to improve safety. 


 

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