College of LAS Events

Back to Listing

If you will need disability-related accommodations in order to participate, please email the contact person for the event.
Early requests are strongly encouraged to allow sufficient time to meet your access needs.

Inorganic Faculty Candidate Seminar: Dr. Wesley Transue, Stanford University, "A Thioether-Ligated Cupric Superoxide Model with Hydrogen Atom Abstraction Reactivity"

Event Type
Seminar/Symposium
Sponsor
Inorganic Chemistry
Location
1024 Chem Annex
Date
Dec 14, 2021   11:15 am  
Speaker
Dr. Wesley Transue
Contact
Wendy Wimmer
E-Mail
wwimmer@illinois.edu
Phone
217-333-2983
Views
59
Originating Calendar
Chemistry - Inorganic/ Materials Chemistry Seminars

Non-coupled binuclear (NCBN) copper monooxygenases are metalloenzymes centrally involved in the biosynthesis of neurotransmitters and signaling peptides. The most famous is dopamine β-monooxygenase, which oxidizes dopamine into norepinephrine through C–H activation. This enzyme family is widely thought to operate through a unique methionine-ligated cupric superoxide intermediate. The copper–sulfur interaction has proven critical for turnover, raising still-unresolved questions on why Nature employs an oxidizable methionine residue within an oxygenation active site. In this seminar, I will describe our recent work on the first cupric superoxide model complex with a demonstrable Cu–S interaction. Resonance Raman, EXAFS (extended X-ray absorption fine structure), and magnetic circular dichroism (MCD) studies will provide insight into the geometric and electronic structures, especially in comparison with an all-nitrogen ligand analog. Hydrogen atom abstraction reactivity will be described, showing this complex to be both a structural and a functional model for the active site of NCBN enzymes. 

link for robots only