"Stress-induced acetylcholine signaling in the hippocampus: too much of a good thing?," by Marina Picciotto, Charles BG Murphy Professor in Psychiatry, Deputy Chair for Basic Science, Professor of Neuroscience and of Pharmacology, Yale University
- Event Type
- Seminar/Symposium
- Sponsor
- Neuroscience Program
- Virtual
- Join online
- Date
- Jan 25, 2022 4:00 pm
- Speaker
- Marina Picciotto, Yale University
- Contact
- Neuroscience Program
- nsp@life.illinois.edu
- Phone
- 217-300-7978
- Views
- 121
- Originating Calendar
- Neuroscience Program Seminars
Acetylcholine (ACh) is often thought of as a neurotransmitter that is important for cognition, but we have identified increased brain ACh levels in human subjects who are actively depressed. This seminar will present data that increasing activity of ACh inputs to the hippocampus selectively induces stress-dependent behaviors, including increased susceptibility to social stress. Our working hypothesis is that ACh signaling in hippocampus may be relevant to the negative encoding bias, that is, increased focus on negative events, experienced by individuals with depression.