Neuroscience Program
4 matches found
-
GABA(A) receptor subtypes that incorporate a delta subunit protein and mediate tonic inhibition are preferentially modulated by neuroactive hormone metabolites and low to moderate doses of alcohol. During this seminar, I’ll share work supporting a role for this GABA(A) receptor subtype in sex-specific alcohol related behaviors and the consequences of binge drinking.
-
Rats and humans alike readily navigate to destinations we have previously visited. This seminar will discuss how representations of those places are stored in the hippocampal formation and then utilized to guide future behavior by transforming that information through cortico-striatal pathways.
-
A better understanding of genetic epilepsy mechanisms is needed to develop precision therapies for patients. To shed light on these mechanisms, we are combining mouse and human pluripotent stem cell models. I will discuss our work modeling genetic epilepsies (SCN8A, PCDH19 and MECP2) using human pluripotent stem cell-derived 2-D neuronal and brain organoid cultures.