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From birth to adulthood, an animal’s nervous system undergoes considerable expansion. Through serial electron microscopy and functional imaging studies, we reveal several developmental principles that govern the structural growth and functional maturation across the wiring diagram of C. elegans.
Reproduction is governed by the coordinated secretion of hormones from the brain & pituitary. The hormones, GnRH & LH, are released in discrete "pulses", whose unique pattern is regulated by many factors. Mechanisms by which endocrine & neural signals modulate reproductive hormone pulses in normal & disease states will be discussed, focusing on findings from mouse models.