Biochemistry Department

Biochemistry Seminar of Special Interest: Dr. Baobin Li (UC Berkeley), "Mechanisms of pH sensory of the two-pore domain K+channel TASK2"

Event Type
Seminar/Symposium
Sponsor
Dr. Satish Nair
Date
Apr 5, 2022   12:00 pm  
Speaker
Dr. Baobin Li
Cost
Free
Contact
Cara Day
E-Mail
caraday@illinois.edu
Phone
217-333-2013
Views
118
Originating Calendar
Biochemistry Department Seminars

TASK2 (also known as KCNK5) channels generate pH-gated leak-type K+currents to control cellular electrical excitability. TASK2 is involved in the regulation of breathing by chemosensory neurons of the retrotrapezoid nucleus in the brainstem and pH homeostasis by kidney proximal tubule cells. These roles depend on channelactivation by intracellular and extracellular alkalization. We determined cryo-electron microscopy structures of TASK2 in lipid nanodiscs in open and closed conformations.These structures were captured in distinctconformations. I will discuss how internal and external protons control intracellular and selectivity filter gates to modulate TASK2 activityand then control the breathing.

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