CANCELLED - CANCELLED - CANCELLED
This seminar has been cancelled. It will be rescheduled at a later date.
Type V CRISPR-Cas systems are featured by RNA-guided Cas12 effector nucleases and have been developed as tools for genome editing and molecular diagnostics. Compared to type II Cas9 effectors that contain both RuvC and HNH nuclease domains, Cas12 effectors only contain a RuvC nuclease domain. The functions of Cas12 effectors are highly diverse, including RNA-guided DNA cleavage, RNA-guided RNA cleavage, and RNA-guided DNA transposition. In this seminar, I will discuss our recent structural and mechanistic studies on Cas12 effectors and their regulation by inhibitor proteins using cryo-EM and biochemical approaches.