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CANCELLED - Biochemistry Seminar: Dr. Leifu Chang (Purdue University), "Structure and mechanism of type V CRISPR-Cas12 effectors"

Event Type
Seminar/Symposium
Sponsor
Department of Biochemistry (Host: Dr. Hong Jin)
Location
Charles G. Miller Auditorium, B102 Chemical and Life Science Laboratory
Date
Nov 11, 2022   12:00 pm  
Speaker
Prof. Leifu Chang
Contact
Cara Day
E-Mail
caraday@illinois.edu
Phone
217-333-2013
Views
53
Originating Calendar
Biochemistry Department Seminars

CANCELLED - CANCELLED - CANCELLED

This seminar has been cancelled. It will be rescheduled at a later date.

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Type V CRISPR-Cas systems are featured by RNA-guided Cas12 effector nucleases and have been developed as tools for genome editing and molecular diagnostics. Compared to type II Cas9 effectors that contain both RuvC and HNH nuclease domains, Cas12 effectors only contain a RuvC nuclease domain. The functions of Cas12 effectors are highly diverse, including RNA-guided DNA cleavage, RNA-guided RNA cleavage, and RNA-guided DNA transposition. In this seminar, I will discuss our recent structural and mechanistic studies on Cas12 effectors and their regulation by inhibitor proteins using cryo-EM and biochemical approaches. 

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