Research Seminars @ Illinois

Spatially charting molecular cell types at single-cell resolution across the entire 3D volume of the brain is critical to illustrating the molecular basis of the tissue anatomy and functions. Yet, there is still a big gap between spatial cell atlas and tissue function. In this presentation, I will introduce a few experimental and computational advances in the mapping of RNA life cycle in our lab that further enable multi-modality deep profiling of cell types and states in situ, bridging single-cell molecular profiles with single-cell functional status in intact biological tissues and accelerating gene-to-function discoveries in development and diseases.