Research Seminars @ Illinois

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Tailored for undergraduate researchers, this calendar is a curated list of research seminars at the University of Illinois. Explore the diverse world of research and expand your knowledge through engaging sessions designed to inspire and enlighten.

To have your events added or removed from this calendar, please contact OUR at ugresearch@illinois.edu

STC-QCB Seminar: Bin Zhang (MIT), "Multiscale Simulations of Biocondensates and Genome Organization"

Event Type
Seminar/Symposium
Sponsor
NSF QCB STC
Location
Beckman 3269 3rd Floor Tower Room
Date
Mar 18, 2024   3:00 - 4:00 pm  
Speaker
Bin Zhang
Contact
Lisa Johnson
E-Mail
lisa3@illinois.edu
Phone
217-300-9574
Views
36
Originating Calendar
Physics - Biological Physics / iPoLS / STC-QCB Seminar

Coarse-grained models enable large-scale simulations of complex biomolecular systems over long timescales. We have introduced bottom-up approaches based on contrastive learning to parameterize these models using atomistic simulations, and top-down approaches based on maximum entropy optimization to parameterize them from experimental data. We performed coarse-grained simulations to study the liquid-liquid phase separation of biomolecules, which has emerged as a fundamental principle for organizing various cellular structures. In addition, we simulate the 3D conformations of the human genome to understand its organizational principles and the role of chromatin structure in gene regulation. Our studies help elucidate the molecular determinants for the stability, internal organization, and coarsening of biocondensates, and the contribution of various condensates to genome organization.

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