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Dr. Perilla

Theoretical & Computational Biophysics Group Seminar: Juan Perilla

Event Type
Seminar/Symposium
Sponsor
Theoretical & Computational Biophysics Group
Location
Beckman Institute Room 3269 (3rd Floor Tower Room)
Virtual
wifi event
Date
Nov 14, 2022   3:00 pm  
Speaker
Juan Perilla, Assistant Professor of Chemistry & Biochemistry, University of Delaware, Newark, Delaware.
Contact
Lesley Butler
E-Mail
lesleym@illinois.edu
Views
9
Originating Calendar
Beckman and Campus Calendars

Title: "Retrovirology through the lens of the computational microscope."

Speaker: Juan Perilla, Assistant Professor of Chemistry & Biochemistry, University of Delaware, Newark, Delaware.

The essential conundrum of modern biology, namely the question of how life emerges from myriad molecules whose behavior is governed by physical law alone, is embodied within a single cell-the quantum of life. The rise of scientific supercomputing has allowed for the study of the living cell in unparalleled detail, from the scale of the atom to a whole organism and at all levels in between. In particular, the past three decades have witnessed the evolution of molecular dynamics (MD) simulations as a 'computational microscope', which has provided a unique framework for the study of the phenomena of cell biology in atomic (or near-atomic) detail. Our work synergistically combines single-molecule biophysics, structural biology and computational biology techniques to probe the molecular origin of biological phenomena. Here I present an overview of our synergistic efforts with experimentalists to determine the molecular details during the life-cycle of HIV-1. Our work reveals complex relationships between capsid permeability and reverse- transcription, and deciphers the role of host-factors during the life- cycle of the virus.

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