Integrative Biology

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Title of the Talk: Tracing Genome Evolution for COVID-19 Predictive Intelligence with Professor Dr. Gustavo Caetano-Anolles

Event Type
New Frontiers Initiative
Dec 13, 2022   10:00 - 11:00 am  
Scott Lathrop
Originating Calendar
CPSC Seminars CSPC

Abstract for Gustavo Caetano-Anollés's talk

Predictive intelligence is a forward-looking strategy that uses past events to anticipate the future. I will report on our efforts to generate predictive intelligence for viral pandemics. Our focus is the evolving COVID-19 virus. The virus continues to represent a worldwide threat despite implementation of public-wide vaccination measures. Analysis of over 12 million genome sequences revealed how viral genetic makeup is being structured by emerging mutant constellations. We found that haplotypes – sets of mutations that are inherited together – were linked to virus seasonality and coalesced into constellations delimiting networks of molecular interactions. We also modelled the changing structure of the ~30 proteins of the COVID-19 genome with powerful deep-learning ab initio structural prediction methods, uncovering a central functional role of protein loop and structural domain regions. Our goal is to develop artificial intelligence and machine learning tools that can be utilized for emergency health security programs.

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