Pharmaceutical manipulation of the hormones glucagon-like peptide-1 (GLP-1) and leptin are viable treatment options for obesity and metabolic diseases. Surprisingly, the cellular mechanisms within the brain mediating GLP-1 and leptin's effects on body weight regulation remain largely unknown. Data presented will show a unique contribution of astrocytes within the brainstem in mediating the food intake and body weight suppressive effects of GLP-1 and leptin.
