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NSP Seminar: Lymphatic-Glymphatic Roles in Alzheimer's Disease

Event Type
Seminar/Symposium
Sponsor
Neuroscience Program
Date
Sep 15, 2020   4:00 pm  
Contact
Stephanie Pregent
E-Mail
spregent@illinois.edu
Views
9
Originating Calendar
Beckman Institute Calendar (internal events only)

Neuroscientist Jonathan Kipnis, Washington University School of Medicine, will talk about "Lymphatic-Glyphatic Roles in Alzheimer's Disease."

Immune cells and their derived molecules have major impact on brain function. Our results demonstrate that meningeal space, surrounding the brain, is the site where CNS-associated immune activity takes place. We discovered a presence of meningeal lymphatic vessels that drain CNS molecules and immune cells to the deep cervical lymph nodes and also regulate perfusion of the brain by CSF (glymphatic flow). This communication between the CNS and meninges is playing a key role in several neurological, primarily in Alzheimer's disease. Interestingly, the integrity of meningeal lymphatics also dictates the response to immunotherapy in AD. Meningeal lymphatics, overall may serve as a novel therapeutic target for neurological disorders. 

No registration is required. Click here to join the Zoom meeting.

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