Exploration of mechanisms underlying malaria pathogenesis
Julie M. Moore
Professor and Head
Department of Infectious Diseases and Immunology
College of Veterinary Medicine
University of Florida
Dr. Moore has been working in the malaria field for more than 30 years. She has employed complementary approaches, including field studies in malaria-endemic western Kenya, development of mouse models, and in vitro cell culture systems to advance understanding of malaria pathogenesis. Her research program transects multiple conceptual and technical scales, ranging from the molecular to epidemiological consideration of disease at the population level. Her research contributions include extensive characterization of immunologic changes in the human placental blood compartment in response to malaria, characterization of genetic diversity of a key placental malaria antigen in Plasmodium falciparum, VAR2CSA, development of mouse models for malaria during pregnancy which simulates the pathogenesis of human P. falciparum infection in pregnant women, recognition of the importance of dysregulated coagulation in placental and cerebral malaria pathogenesis, exploration of programmed cell death pathways in placental malaria, and elucidation of the fetal contribution to local immunity in the malaria-infected human placenta. Recent work also explores the relationships between malaria and the microbiome during pregnancy.
Thursday, April 22, 2021 at 12:00 p.m.
Meeting URL: https://illinois.zoom.us/j/81091972681?pwd=Z1lLWmFNWHNCaU1wK3Zyb05kVlMvZz09
Meeting ID: 810 9197 2681
Password: 071159
For more information contact the Department of Pathobiology at 217-333-2449, email klp68@illinois.edu.
