Beckman Institute Calendar (Master)

View Full Calendar

STC for Quantitative Cell Biology Seminar: Bin Zhang

Event Type
Lecture
Sponsor
STC for Quantitative Cell Biology Seminar Series
Location
Beckman Institute Room 3269 (3rd floor tower room)
Virtual
wifi event
Date
Mar 18, 2024   3:00 pm  
Speaker
Bin Zhang, MIT
Contact
Lisa Johnson
E-Mail
lisa3@illinois.edu
Views
1
Originating Calendar
Beckman Institute Calendar (internal events only)

Bin Zhang, MIT, will lecture on "Multiscale Simulations of Biocondensates and Genome Organization"

Abstract: Coarse-grained models enable large-scale simulations of complex biomolecular systems over long timescales. We have introduced bottom-up approaches based on contrastive learning to parameterize these models using atomistic simulations, and top-down approaches based on maximum entropy optimization to parameterize them from experimental data. We performed coarse-grained simulations to study the liquid-liquid phase separation of biomolecules, which has emerged as a fundamental principle for organizing various cellular structures. In addition, we simulate the 3D conformations of the human genome to understand its organizational principles and the role of chromatin structure in gene regulation. Our studies help elucidate the molecular determinants for the stability, internal organization, and coarsening of biocondensates, and the contribution of various condensates to genome organization.


link for robots only