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Mohsen Sadeghi

Theoretical & Computational Biophysics Group Seminar

Event Type
Beckman Institute for Advanced Science and Technology
Aug 1, 2022   3:00 pm  
Mohsen Sadeghi, Post Doctoral Researcher, Freie Universit├Ąt Berlin, Berlin, Germany
Attend in person at 3269 Beckman Institute or join via Zoom
Lesley Butler
Originating Calendar
Beckman and Campus Calendars

Title: Dynamic modeling framework for large-scale simulation of biomembranes and flexible peripheral proteins

Speaker: Mohsen Sadeghi, Post Doctoral Researcher, Freie Universitat Berlin, Berlin, Germany

Membrane-associated peripheral proteins are, among other tasks, responsible for shaping and remodeling biomembranes. The necessary cooperative action of a multitude of curvature-inducing proteins is often facilitated by indirect membrane-mediated interactions. This renders the quantitative analysis of the dynamics of a collection of peripheral proteins in a consistent model that incorporates membrane kinetics as well as protein flexibility and lateral dynamics quite essential in fully describing protein aggregation and membrane remodeling processes. In this talk, I will present my dynamic membrane modeling framework [1-3], and discuss quantitative results on membrane- mediated interactions, aggregation kinetics, free energy landscapes, and entropy change governing the formation and break-up of protein clusters on the surface of the membrane.

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