What might account for the massive loss of amphibian species over the last thirty years all around the world? The list of suspects turns out to be a who's who of global environmental challenges. Tracking the culprits will require the ingenuity of natural and social scientists, and stopping them will require the tenacity of lawyers. And as the chase goes on, we will all need to face the fact that our own actions, small and large, can have impacts far and wide.