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Bhargava

Biological Physics (iPoLS) Seminar: Rohit Bhargava

Event Type
Seminar/Symposium
Sponsor
Center for Biophysics and Quantitative Biology
Location
Beckman Institute Room 3269 (3rd Floor Tower Room)
Virtual
wifi event
Date
Oct 14, 2022   2:00 pm  
Speaker
Rohit Bhargava, Founder Professor in Bioengineering, The Grainger College of Engineering, University of Illinois Urbana Champaign.
Contact
Sharlene Denos
E-Mail
denos@illinois.edu
Views
10
Originating Calendar
Beckman Institute Calendar (only)

Title: “Progress in chemical imaging to record structure and chemistry in biological materials”

Speaker: Rohit Bhargava, Founder Professor in Bioengineering, The Grainger College of Engineering, University of Illinois Urbana Champaign.

Infrared (IR) spectroscopic imaging allows the recording of molecular and structural properties of complex samples without the need for prior information on composition, dyes, or stains. The spatial and spectral domains are coupled, presenting both opportunities and challenges for recording high-content, high-fidelity data that determine image quality. Dr. Bhargava first provides an optical theoretic and information theoretic approach to present a roadmap for the development of optical microscopy-based imaging. His team's research shows how spatial quality is related to spectral data and provides explicit relationships to devise imaging configurations at performance limits. He will show how molecular content over large areas can be recorded by new high-speed microscopy configurations and present rigorous approaches to extending molecular understanding with linear and circularly polarized light. Finally, Dr. Bhargava will present a detailed theoretical understanding of image formation in nanoscale spectroscopic imaging using an atomic force microscope in contact mode. A new method, based on null deflection of the cantilever, is introduced to provide high-quality data.

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