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Dr. Yvonne Tay Mei Sian, Cancer Science Institute of Singapore: “Widespread 3’UTR splicing promotes oncogene expression and tumorigenesis”

Event Type
Seminar/Symposium
Sponsor
Cell and Developmental Biology
Location
Charles G. Miller Auditorium B102 CLSL
Date
Jan 25, 2023   12:00 pm  
Speaker
Dr. Yvonne Tay Mei Sian
Contact
Laura Martin
E-Mail
lmmartin@illinois.edu
Phone
217-265-0046
Views
20
Originating Calendar
Cell and Developmental Biology (CDB) Departmental Seminars

“Widespread 3’UTR splicing promotes oncogene expression and tumorigenesis”

Major research interests: In addition to genomic alterations, aberrant changes in post-transcriptional regulation by factors including RNA binding proteins and non-coding RNAs represent another mechanism to modify gene function and thus contribute to tumorigenesis. In addition to studying non-coding RNAs in their own right, our group is also interested in studying the non-coding regions of protein-coding mRNAs (untranslated regions, UTRs). Our work has three main focus areas: (1) Deconvoluting RNA:RNA networks in cancer; (2) Understanding the interplay between RNA:RNA interactions and RNA:protein interactions and (3) Examining potential crosstalk between these post-transcriptional networks and RNA processing pathways such as alternative splicing and polyadenylation. Our long-term goal is to translate our basic research discoveries into new avenues for the development of novel RNA-based anti-cancer diagnostics and therapeutics.

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