Cells within load-bearing soft tissues sense and respond to diverse stimuli, including mechanobiological and immunobiological. Mechanical homeostasis is a ubiquitous process by which certain mechanical quantities are regulated to remain, within a range, near a preferred value, often called a set point. As an example, both flow-induced wall shear stress and pressure-induced intramural stress tend to be mechano-regulated to remain close to region-specific set-points in vascular mechanics. In some cases, inflammation can support mechanical homeostasis while in other cases it can prevent such homeostasis.
In this talk, we will consider two cases wherein it is important to model both the mechanical and the inflammatory signals and responses, illustrated here for blood vessels. In the first case, we will consider the in vivo development of a tissue engineered neovessel from an implanted polymeric implant. In the second case, we will consider the growth and remodeling of a native artery in a mouse model of induced hypertension. Although inflammation arises for very different reasons in these two cases, we shall see how a consistent constrained mixture model of growth and remodeling can be used to predict the evolving geometry, composition, and wall properties in both cases. Importantly, computational predictions in the tissue engineered case helped lead to US Food and Drug Administration (FDA) approval of a clinical trial of a promising technology for treating congenital heart defects in children, thus showing translational potential of immuno-mechanical computational models of tissue response. For more information, please find details presented elsewhere.
J.D. Humphrey is the John C. Malone Professor of Biomedical Engineering at Yale University. He received the Ph.D. in Engineering Science and Mechanics from The Georgia Institute of Technology and completed a post-doctoral fellowship in Medicine - Cardiovascular at Johns Hopkins University. His research and teaching focuses on vascular mechanics and mechanobiology, with particular interest in development, hypertension, aneurysms, vascular aging, and tissue engineering. He has authored a graduate textbook (Cardiovascular Solid Mechanics), an undergraduate textbook (An Introduction to Biomechanics), and a handbook (Style and Ethics of Communication in Science and Engineering), and published 350+ archival journal papers. He served for 10 years as founding co-editor for the journal Biomechanics and Modeling in Mechanobiology, for 12 years on the World Council for Biomechanics, including as Chair of the Technical Program of the 2014 World Congress in Biomechanics, and served for two years as Chair of the US National Committee on Biomechanics. He lives with his wife Rita of 41 years in Branford, CT.
Host: Professor Shelby Hutchens and Professor Callan Luetkemeyer