The numbers of people undernourished, unable to afford a healthy diet, or facing a food emergency have spiked over the past decade, reversing decades of rapid progress. Effectively tackling those food security challenges requires a holistic perspective that also addresses inextricably related crises of climate change, conflict, emergent infectious diseases, air and water pollution, and poverty. This talk integrates a wide body of research to advance a feasible vision of agrifood systems transformation to overcome these interlinked polycrises.