Department of Chemistry Master Calendar

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This calendar includes all events from the following individual calendars: Department of Chemistry Alumni Events (events for an alumni audience), Department Events (events of general interest and/or relevant to all Chemistry research areas), Diversity, Equity, and Inclusion Events, Public Events, and events related to Chemistry research areas and programs (Analytical Chemistry, Chemical Biology, Chemistry-Biology Interface Training Program, Inorganic Chemistry & Materials Chemistry, Organic Chemistry, Physical Chemistry), as well as Department of Chemical and Biomolecular Engineering Seminars & Events.


Distinguished Lecture in Physical Chemistry: Prof. Christy Landes, Rice University, "Towards predictive protein separations: Imaging protein dynamics at nanoscale interfaces"

Event Type
Physical Chemistry
Jan 4, 2023   2:00 pm  
Jackie Miller
Originating Calendar
Chemistry - Physical Chemistry Seminars

Towards predictive protein separations: Imaging protein dynamics at nanoscale interfaces


Recent efforts by our group and others have shown the promise of applying single molecule methods to link mechanistic detail about protein adsorption to macroscale observables. When we study one molecule at a time, we eliminate ensemble averaging, thereby accessing underlying heterogeneity. However, we must develop new methods to increase information content in the resulting low density and low signal-to-noise data and to improve space and time resolution.

            I will highlight recent advances in super-resolution microscopy for quantifying the physics and chemistry that occur between target proteins and stationary phase supports during chromatographic separations. My discussion will concentrate on the newfound ability of super-resolved single protein imaging to inform theoretical parameters via quantification of adsorption-desorption dynamics, protein unfolding, and nano-confined transport. Additionally, I will discuss using phase manipulation to encode temporal and 3D spatial information, and the opportunities and challenges associated with such imaging methods.




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