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Inorganic Faculty Candidate Seminar: Dr. Wesley Transue, Stanford University, "A Thioether-Ligated
Cupric Superoxide Model with Hydrogen Atom Abstraction Reactivity"
- Event Type
- Seminar/Symposium
- Sponsor
- Inorganic Chemistry
- Location
- 1024 Chem Annex
- Date
- Dec 14, 2021 11:30 am
- Speaker
- Dr. Wesley Transue
- Contact
- Wendy Wimmer
- E-Mail
- wwimmer@illinois.edu
- Phone
- 217-333-2983
- Views
- 138
- Originating Calendar
- Chemistry - Inorganic/Materials Chemistry Seminars
Non-coupled binuclear (NCBN) copper monooxygenases are metalloenzymes centrally involved in the biosynthesis of neurotransmitters and signaling peptides. The most famous is dopamine β-monooxygenase, which oxidizes dopamine into norepinephrine through C–H activation. This enzyme family is widely thought to operate through a unique methionine-ligated cupric superoxide intermediate. The copper–sulfur interaction has proven critical for turnover, raising still-unresolved questions on why Nature employs an oxidizable methionine residue within an oxygenation active site. In this seminar, I will describe our recent work on the first cupric superoxide model complex with a demonstrable Cu–S interaction. Resonance Raman, EXAFS (extended X-ray absorption fine structure), and magnetic circular dichroism (MCD) studies will provide insight into the geometric and electronic structures, especially in comparison with an all-nitrogen ligand analog. Hydrogen atom abstraction reactivity will be described, showing this complex to be both a structural and a functional model for the active site of NCBN enzymes.
