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"Regulation of endocannabinoids and related lipids by THC and CBD: effects of sex, enzymes, and development?," by Professor Heather Bradshaw Department of Psychological and Brain Sciences Indiana University

Event Type
Seminar/Symposium
Sponsor
Neuroscience Program
Location
https://illinois.zoom.us/j/83566081431?pwd=VllERlduN0hrUUYzQ1p0YTk2U2xKZz09
Virtual
wifi event
Date
Sep 28, 2021   4:00 pm  
Speaker
Heather Bradshaw, Indiana University
Contact
Neuroscience Program
E-Mail
nsp@life.illinois.edu
Phone
217-300-7978
Views
55
Originating Calendar
Neuroscience Program Seminars

Multiple lines of evidence support the hypothesis that the cannabinoids, THC and CBD, do more than act on specific GPCRs.  Recent evidence in my laboratory points to how cannabinoids drive broad changes in the lipidome with data suggesting that many of the changes are dependent on the enzyme NAPE-PLD.  We have also shown that cannabinoid effects on the lipidome are sex and age dependent.  Taken together, these data provide a novel framework for how cannabinoids change multiple signaling pathways by fundamentally changing lipid signaling throughout the CNS.  

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