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"DART: A New Way to Study Brain Dynamics, Drugs, and Disease," Michael Tadross, M.D.,Ph.D., Duke University, Assistant Professor Depts. of Biomedical Engineering & Neurobiology

Event Type
Seminar/Symposium
Sponsor
Neuroscience Program
Location
Beckman Institute 1005
Date
Oct 29, 2019   4:00 pm  
Speaker
Michael Tadross, Duke University
Contact
Uwe Rudolph
E-Mail
urudolph@illinois.edu
Views
163
Originating Calendar
Neuroscience Program Seminars

There has been a surge in technologies to observe how genes and proteins change in the brain during disease. Yet, it has remained difficult to distinguish cause from effect; whether a given protein change in a specific cell type is the cause of behavioral impairments, a compensatory phenomenon, or simply an epiphenomenon. I will describe a new method, DART (drugs acutely restricted by tethering), to rapidly restrict drugs to genetically defined neurons in behaving mice. The approach offers a new way to establish causal circuit and molecular substrates of normal and aberrant behavior.

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