Neuroscience Program
5 matches found
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Both computational & experimental results in single neurons & small networks demonstrate that similar network function can result from quite disparate sets of neuronal & network paramaters. We show that neurons with many different kinds of ion channels can smoothly move through different mechanisms in generating their activity patterns, thus extending their dynamic range.
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We examine the brain processes involved in interactive vocal behaviors, focusing on forebrain circuitry in the songbird and the rodent, and we relate these to emerging human studies that employ a range of methods to manipulate and monitor cortical areas relevant for speech.
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Immune cells and their derived molecules have major impact on brain function. Our results demonstrate that meningeal space, surrounding the brain, is the site where CNS-associated immune activity takes place. Meningeal lymphatics, overall, may serve as a novel therapeutic target for neurological disorders.
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Genomic imprinting in the mammalian brain is hypothesized to regulate aspects of social behavior. These studies reveal regions of the mouse brain containing cell subpopulations with dominant maternal allele expression of dopa decarboxylase (Ddc), a monoamine neurotransmitter synthesis enzyme.
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Connectome-based predictive modeling is powerful approach to model individual differences in phenotypes using fMRI data. One limitation of this approach is that models are complex, making it challenging to target these models with interventions. Here, I will discuss our recent work in creating these models and developing potential approaches to target them.