Molecular and Integrative Physiology (MIP) Department
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Lab Interests: Liver injury and repair: To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver disease
Research Interests: Epilepsy; autism; neurodevelopmental disease
What they do How do neurons in neocortex work in concert to encode the natural world, construct a representation of its behaviorally relevant content, and coordinate behavior based on those representations? This is a complex problem that we are addressing in multiple ways, with an interdisciplinary and comparative approach.
Research Interest: The liver is a vital organ with a wide range of functions, including detoxification of various metabolites, protein synthesis, synthesis of bile acids, and, broadly, regulation of metabolism. Our laboratory's goal is to understand how these processes are regulated within the liver.
Molecular & Integrative Physiology Seminar: MIP Students, Jessica Saw (Sweedler Lab) "“Geobiology Reveals How Human Kidney Stones Dissolve in Vivo" & Jiaren Zhang (Hee Chung Lab) "Missense Epileptic Encephalopathy Mutations in Neuronal KCNQ/Kv7 Channels Occur at Hotspots within Highly Conserved Functional Domains of Kv7.2 and Kv7.3."
Our long-term goal is to understand the transcriptional regulatory network in metabolism. We are currently pursuing two major projects. MLL3/4 complexes in transcription and Central roles of glucocorticoid in metabolism.
Molecular neuroscience, fragile X syndrome
Areas of Interest: Genetics of Birth Defects: neuroendocrine, auditory, and skeletal development. We use two main approaches in our birth defects research - sequencing patient DNA to identify novel disease genes and use of cell culture and animal models, especially the mouse, to understand the mechanism and pathophysiology of disease.
Research in the Wendt lab focuses on the molecular mechanisms of breast cancer metastasis. Research in his lab uses a combination of genetics, cell biology and in vivo imaging to identify and target key signaling processes involved in breast cancer metastasis.
The primary emphasis of our laboratory is to understand the alterations among insulin signaling, bioenergetics, glutamatergic neurotransmission, and cognition that occur during disease progression versus successful aging.