Neuroscience Program Seminars
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Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimer’s disease (AD); Our findings reveal that the presynaptic terminal is particularly vulnerable and represents a critical site for manifestation of initial AD etiology.
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Thyroid hormone is key to every process in the body and its regulation is disrupted during illness, obesity and weight loss. Our laboratory hypothesizes the neuroendocrine thyrotropin-releasing hormone (TRH) neurons are the integrator of peripheral signals to regulate thyroid hormone levels and we are using a combination of genetic mouse models and chemogenetics.