"Cellular and Molecular Mechanisms Underlying FXS Pathophysiology and its Gene-Therapy Strategies"
The Lee Lab Focuses on:
1) Identifying the molecular mechanisms responsible for the pathophysiology of autism and related disorders, and using these mechanisms to rescue behavioral dysfunction in mouse models.
2) Elucidating specific autistic behaviors including social communication deficits and repetitive behaviors, and identifying the brain region(s) and neuron groups underlying these behavioral deficits in mouse models. To address these questions, Dr. Lee uses molecular and cellular neurobiology tools, in vivo brain imaging, and animal behavioral studies.