Title: "Interneuron hypofunction in Fragile X Syndrome"
A symptom to circuit approach to understand autism
- How are cortical circuits assembled during typical brain development?
- What are the underlying circuit defects in autism and intellectual disability?
- What are the best ways to model neuropsychiatric symptoms?
We are trying to answer these questions using the latest state of the art tools in neuroscience research, such as in vivo 2-photon calcium imaging and silicon probes to record network activity, chemogenetics with DREADDs or optogenetics to manipulate neuronal activity, and sophisticated behavioral tasks.