This seminar will be held in room 1005 Forbes Natural History building, 1816 S Oak Street, Champaign or you may join Zoom: here Meeting ID: 810 4865 3784 | Password: 334751
The goal of tick vaccine research is to develop sustainable interventions to decrease the incidence of tick-borne diseases. Bovine anaplasmosis is caused through transmission of the rickettsial bacteria Anaplasma marginale via tick bite or mechanical transmission during ear tagging, dehorning, or castration. While domestic cattle are most frequently affected, all ruminant animals are susceptible to persistent, lifelong infection. Cattle are permissive hosts to numerous tick and tick-borne pathogen species and most of the known tick-borne diseases of cattle are well-characterized. Thus, the overall objective of this study was to adapt an established immunization protocol to the experimental tick transmission model of bovine anaplasmosis. Previously described procedures to immunize hosts with crude extracts of tick midgut or salivary glands were initially tested for the ability to induce resistance to infestation with Dermacentor andersoni ticks. After host seroconversion and resistance to ticks were observed, this model was adapted to test for intervention with biologic transmission of A. marginale. This presentation will review the results of these studies and the evidence that the bovine-A. marginale-Dermacentor spp. tick interaction is feasible as a model system for discovery and development of anti-tick vaccine candidates.