One-Click Link: https://illinois.zoom.us/j/83601615314?pwd=cktKVERMZUdoUDlJclE2dCtVTkJwdz09
Zoom Meeting ID: 836 0161 5314, Password: 105431
Abstract: Biomolecules are exquisitely adept at molecular recognition and self-assembly, enabling them to direct all of the processes that make life possible. These capabilities have been fine-tuned by billions of years of evolution, and more recently, have been harnessed in the laboratory to enable the use of biomolecules for applications beyond their canonical biological roles. The common thread that is woven throughout our research program is the utilization of nucleic acid molecular recognition and self-assembly to generate functional architectures for biosensing and bioimaging. We have harnessed photoaffinity labeling to covalently tag specific RNA transcripts with small-molecule fluorophore, subsequently enabling visualization of RNA localization and dynamics in living cells. We have also demonstrated the modulation of EndoV activity to enable selective enrichment of inosine-containing RNAs, which has enabled the identification of new A-to-I editing sites.
Bio: Jen received her B.S. in Chemistry from the University of California, Irvine, in 2000. At Irvine, she performed undergraduate research with Prof. James Nowick investigating the folding of synthetic beta-sheet mimics, which instilled in her a love of supramolecular chemistry. Jen then moved to the University of Illinois, Urbana-Champaign, where she completed her Ph.D. with Prof. Jeffrey Moore in 2005 studying the reactivity of pyridine-functionalized phenylene ethynylene cavitands. After a brief stint in industry as a medicinal chemist, she moved to Harvard University to pursue postdoctoral research with Prof. David Liu exploring mechanisms for templated nucleic acid synthesis. In 2010, Jen began her independent career in the Department of Chemistry at the University of Utah, and was promoted to Associate Professor with tenure in 2016. In 2017, Jen and her research group moved to the Department of Chemistry at Emory University. Research in the Heemstra lab is focused on harnessing the molecular recognition and self-assembly properties of nucleic acids for applications in biosensing and bioimaging. Outside of work, Jen enjoys spending time with her husband and two sons, as well as rock climbing, cycling, and running.
