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The Hidden Mechanisms of Bacterial Transcription Termination Revealed by Single-Molecule Fluorescence Measurements

Event Type
UIUC Center for the Physics of Living Cells (CPLC)/International Physics of Living Systems
via zoom (see description for info)
Oct 30, 2020   2:00 pm  
Sungchul Hohng, Department of Physics & Astronomy, Seoul National University, Seoul, Korea
Sharlene Denos
Originating Calendar
Physics - Biological Physics (CPLC/iPoLS) Seminar

Abstract: Gene expression is regulated at not only initiation but also many other stages that follow the initiation stage. The dynamic nature of transcription and its regulation, however, cannot be fully captured in the experiments at the ensemble level, and as a result several key questions concerning gene regulation mechanisms during transcription remain poorly answered. In this talk, I will inroduce the single-molecule fluorescence assays that we developed, and siscuss the mechanisms of the factor-independent and factor-dependent transcription terminations of E. coli Revealed by the utilization of the techniques.


Bio: Professor Hohng received his B.S. in Physics from Seoul National University, Seoul, Korea in 1994; He went on to receive his M.S. in Physics from Seoul National University, Seoul, Korea in 1996; He then received his Ph.D. in Physics from Seoul National University, Seoul, Korea in 2000. Professor Hohng joined Seoul National University as a Postdoctoral Research Associate in 2000 and eventually as faculty in 2006. His research interests are in the areas of Genome Maintenance, Transcription & Chromatin Remodeling: RNA Biology; Development of Novel Single-Molecule and Superreolution Imaging Techniques.

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