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Biochemistry Seminar: Dr. Andrew Gulick (The State University of New York at Buffalo), "Structural Studies of Antibiotic Production by Nonribosomal Peptide Synthetases"

Event Type
Seminar/Symposium
Topics
academic, biochemistry, genomics, physics
Sponsor
Sponsored by Department of Biochemistry, Dr. Satish Nair
Location
Charles G. Miller Auditorium (B102 CLSL)
Date
Nov 22, 2019   12:00 pm  
Speaker
Dr. Andrew Gulick
Cost
Free
Contact
Sherry Unkraut
E-Mail
sunkraut@illinois.edu
Phone
217-333-2013
Views
48
Originating Calendar
Biochemistry Department Seminars

Roughly half of the recently approved FDA pharmaceuticals are derived from natural products, molecules that are produced by microorganisms that enable them to adapt to diverse environments. One class of important natural products are produced by the Nonribosomal Peptide Synthetases (NRPSs), a family of large proteins that contain multiple catalytic domains joined in a single modular protein. Through structural and functional studies of multidomain NRPSs, we have sought to understand the features that guide the efficient biosynthesis of these important enzymes. We have also recently explored the structural basis for catalysis of unusual reactions catalyzed by NRPS proteins involved in the production of antibiotics and peptide siderophores.

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