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CPLC Seminar: Kai Zhang (UIUC) "Bidirectional optogenetic control of growth factor signaling during cell differentiation and embryonic development"

Event Type
Seminar/Symposium
Sponsor
Sangjin Kim
Location
144 Loomis
Date
Sep 27, 2019   2:00 pm  
Speaker
Kai Zhang (UIUC)
Contact
LaShonya Quince
E-Mail
lquince@illinois.edu
Phone
217-300-6726
Views
6
Originating Calendar
Physics - Biological Physics (CPLC/iPoLS) Seminar

The neurotrophic signaling pathway regulates a wide spectrum of cellular functions such as cell survival, proliferation, differentiation, and apoptosis. It also plays a key role in cell fate determination during embryonic development. Evidence suggests that the signaling output of the neurotrophic pathway varies with its temporal kinetics. However, a quantitative delineation of signaling kinetics is limited due to a lack of tools that allows precise control of the neurotrophic signaling in time and space. Non-neuronal optogenetics, an emerging technology that utilizes light to control intracellular signaling pathways, offer an alternative solution to address this challenge. In this presentation, I will introduce optogenetic systems recently developed in our laboratory that allow for reversible and bidirectional optical control of neurotrophic signaling pathway in intact cells and in developing Xenopus laevis embryos. I will also discuss the limitations of current non-neuronal optogenetics and update you with current progress in the field in overcoming these limitations.

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