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Biochemistry Seminar: Dr. Aaron Goldstrohm (University of Minnesota), "Post-transcriptional regulatory functions of Pumilio proteins in development and disease"

Event Type
Seminar/Symposium
Topics
academic, biochemistry
Sponsor
Dr. Auinash Kalsotra
Location
Charles G. Miller Auditorium (B102 CLSL)
Date
Jan 18, 2019   12:00 pm  
Speaker
Dr. Aaron Goldstrohm
Cost
Free
Contact
Sherry Unkraut
E-Mail
sunkraut@illinois.edu
Phone
217-333-2013
Views
32
Originating Calendar
Biochemistry Department Seminars

Dr. Goldstrohm and his team seek to understand how gene expression is regulated at the post-transcriptional level. Regulation of translation, degradation and localization of mRNAs contributes to the enormous dynamic range of protein expression. Sequence specific RNA-binding factors, both protein and small RNAs, play a central role in mRNA regulation. Our research focuses on Pumilio proteins, which are cytoplasmic RNA-binding proteins that control diverse processes including stem cell fate and neurological functions, such as behavior and memory formation. Novel findings show that dysfunction of Pumilio proteins contributes to neurodegeneration, epilepsy, movement disorders, intellectual disability, infertility, and cancer. In this presentation, we explore the impact of Pumilio proteins on gene expression and discuss insights into the mechanisms of RNA binding, translational control, and mRNA destruction.

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