This presentation focuses on the role for carbon capture and storage (CCS) in a portfolio of mitigation options as a basis for strategies to advance the CCS option. Using examples from different projects that employ the MIT Economic Projection and Policy Analysis (EPPA) model, we will examine different long-term scenarios to explore the importance of factors influencing advanced technology deployment, including CCS on power generation, cement, iron and steel in different parts of the world. Pathways for decarbonization of global and regional economies will be assessed.