- Sponsor
- Beckman Institute for Advanced Science and Technology
- Speaker
- Mohsen Sadeghi, Post Doctoral Researcher, Freie Universität Berlin, Berlin, Germany
- Registration
- Attend in person at 3269 Beckman Institute or join via Zoom
- Contact
- Lesley Butler
- lesleym@illinois.edu
- Views
- 28
- Originating Calendar
- Beckman and Campus Calendars
Title: Dynamic modeling framework for large-scale simulation of biomembranes and flexible peripheral proteins
Speaker: Mohsen Sadeghi, Post Doctoral Researcher, Freie Universitat Berlin, Berlin, Germany
Membrane-associated peripheral proteins are, among other tasks, responsible for shaping and remodeling biomembranes. The necessary cooperative action of a multitude of curvature-inducing proteins is often facilitated by indirect membrane-mediated interactions. This renders the quantitative analysis of the dynamics of a collection of peripheral proteins in a consistent model that incorporates membrane kinetics as well as protein flexibility and lateral dynamics quite essential in fully describing protein aggregation and membrane remodeling processes. In this talk, I will present my dynamic membrane modeling framework [1-3], and discuss quantitative results on membrane- mediated interactions, aggregation kinetics, free energy landscapes, and entropy change governing the formation and break-up of protein clusters on the surface of the membrane.