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CPLC Seminar: Jared Schrader (Wayne State University) "Biomolecular condensation organizes the bacterial mRNA decay pathway"

Event Type
Seminar/Symposium
Sponsor
Sangjin Kim
Location
144 Loomis
Date
Sep 20, 2019   2:00 pm  
Speaker
Jared Schrader (Wayne State University)
Contact
LaShonya Quince
E-Mail
lquince@illinois.edu
Phone
217-300-6726
Views
18
Originating Calendar
Physics - Biological Physics (CPLC/iPoLS) Seminar

Bacteria have distinct challenges to organize their cellular pathways as they generally lack membrane-bound organelles. In eukaryotes, membraneless organelles called biomolecular condensates provide distinct liquid-liquid phase separated structures that organize cellular components. We discovered the first biomolecular condensate type of organelle in bacteria that we termed Bacterial Ribonucleoprotein bodies (BR-bodies) composed of the RNA degradosome multi-protein complex and cellular mRNAs. Here we will describe how the bacterium Caulobacter crescentus organizes ribonucleases, RNA helicases, and mRNA substrates into BR-bodies which stimulate mRNA decay. We find that the intrinsically disordered region of RNase E controls the subcellular localization pattern of BR-bodies, and its ability to form BR-bodies is conserved across α-proteobacteria. We propose that the formation of similar biomolecular condensate organelles may provide a particularly effective strategy for spatially organizing biochemical pathways in bacteria.

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