Research Seminars @ Illinois

View Full Calendar

Tailored for undergraduate researchers, this calendar is a curated list of research seminars at the University of Illinois. Explore the diverse world of research and expand your knowledge through engaging sessions designed to inspire and enlighten.

To have your events added or removed from this calendar, please contact OUR at ugresearch@illinois.edu

Hassel and Marianne Ledbetter MatSE Colloquium - "Multiscale Control of Dynamic Hydrogels for Bioinspired Applications"

Event Type
Seminar/Symposium
Sponsor
Department of Materials Science and Engineering/Department of Chemical and Biomolecular Engineering
Location
CIF Auditorium, Room 0027/1025, 1405 W. Springfield Avenue
Date
Feb 26, 2024   4:00 pm  
Speaker
Adrianne Rosales, Department of Chemical Engineering, The University of Texas at Austin
Contact
Bailey Peters
E-Mail
bnpeters@illinois.edu
Phone
217-333-1441
Views
49
Originating Calendar
MatSE Colloquium Calendar

"Multiscale Control of Dynamic Hydrogels for Bioinspired Applications"

Hydrogels with dynamic linkers have garnered intense interest as extracellular matrix (ECM) mimics and injectable delivery vehicles due to their tailorable viscoelasticity, stress relaxation, and self-healing behavior. While dynamic hydrogels with a range of moduli and stress relaxation times have been developed, there remains a need to understand how linking chemistry affects gelation and nonlinear rheological properties. In this context, we have developed synthetic multi-arm poly(ethylene glycol) (PEG) hydrogels with three different dynamic covalent linking chemistries: boronic ester, hydrazone, and thia-conjugate addition bonds. This suite of dynamic covalent linkages allows control over the bond exchange kinetics across three orders of magnitude, which dictates hydrogel viscoelasticity under small amplitude oscillatory shear. Interestingly, the hydrogel moduli demonstrate unique scaling behavior at low concentrations. Furthermore, they exhibit non-monotonic flow curves under steady shear, with shear thickening behavior that depends on the crosslinking bond exchange kinetics and polymer concentration. At high shear, the dynamic hydrogels are injectable, with faster bond exchange kinetics leading to lower injection forces. Overall, these results provide insight to the molecular and structural characteristics that govern dynamic covalent PEG gelation, mechanics, and flow, while also expanding the types of scaffolds applicable to tissue engineering and therapeutic delivery.


link for robots only