A major research focus in the lab is on the chloride-selective CLC family, which contains both types ion-transport protein, channels and transporters. CLC proteins are expressed ubiquitously and perform diverse physiological functions in cardiovascular, neuronal, muscular, and epithelial tissue. Our lab uses a combination of biophysical methods to investigate membrane-protein structure and dynamics together with electrophysiological analyses to directly measure function to determine the molecular mechanisms of these proteins.
We also apply our expertise on ion-transport mechanisms to interdisciplinary collaborations:
https://med.stanford.edu/maduke.html