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Midwest Mathematical Biology Seminar

Event Type
Seminar/Symposium
Sponsor
Department of Mathematics
Virtual
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Date
Feb 21, 2025   3:00 pm  
Speaker
Chengcheng Huang (University of Pittsburgh)
Contact
Daniel Cooney
E-Mail
dbcoone2@illinois.edu
Phone
914-563-4916
Views
17
Originating Calendar
Mathematical Biology Calendar

Speaker: Chengcheng Huang (University of Pittsburgh)

Title: State modulation in spatial networks of multiple interneuron subtypes

Abstract: Neuronal responses to sensory stimuli can be strongly modulated by animal's brain state.  Three distinct subtypes of inhibitory interneurons, parvalbumin (PV), somatostatin (SOM), and vasoactive intestinal peptide (VIP) expressing cells, have been identified as key players in flexibly modulating network activity. The three interneuron populations have specialized local microcircuit motifs and are targeted differentially by neuromodulators and top-down inputs from higher-order cortical areas. However, the specific contribution of each interneuron subtype remains unclear. In this work, we study the function of each interneuron cell type in a spatially ordered spiking neuron network. We find that the firing rates of the SOM neurons align closely with the level of network synchrony irrespective of the target of modulatory input. Further analysis reveals that inhibition from SOM to PV interneurons must be limited to allow gradual transitions from asynchrony to synchrony and that the strength of recurrent excitation onto SOM neurons determines the level of synchrony achievable in the network.  Overall, our results highlight common dynamic regimes achieved across modulations of different cell populations and identify SOM cells as the main driver of network synchrony.

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