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Mathematical Biology Seminar: Understanding the role of phenotypic switching in cancer drug resistance

Event Type
Seminar/Symposium
Sponsor
N/A
Location
Via Zoom. Please email zrapti@uiuc.edu for link.
Date
Sep 9, 2021   1:00 pm  
Speaker
Jasmine Foo (University of Minnesota Twin Cities, Mathematics)
Contact
Zoi Rapti
E-Mail
zrapti@uiuc.edu
Views
8

Abstract: Recent findings suggest that cancer cells can acquire transient resistant phenotypes via epigenetic modifications and other non-genetic mechanisms. Although these resistant phenotypes are eventually relinquished by individual cells, they can temporarily ’save’ the tumor from extinction and enable the emergence of more permanent resistance mechanisms. These observations have generated interest in the potential of epigenetic therapies for long-term tumor control or eradication. In this talk, I will discuss some mathematical models for exploring how phenotypic switching at the single-cell level affects resistance evolution in cancer. As an example, we will explore the role of MGMT promoter methylation in driving resistance to temozolomide in glioblastoma.

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