Hematopoietic Regulation of Stress-Induced Anxiety
Daniel B. McKim, PhD
Department of Animal Sciences
University of Illinois at Urbana-Champaign
The McKim lab investigates bidirectional immune and brain communication in the context of stress and disease. We’ve shown that neuroendocrine activation during psychological stress enhances the myelopoietic production of inflammatory monocytes and granulocytes that traffic to the brain. The dynamic interaction of myeloid cells with vascular brain endothelial cells and resident microglia propagate neuroinflammatory signaling that regulates mood, cognition, and behavior. Similarly, systemic inflammation associated with peripheral disease (e.g., solid tumors, cardiovascular disease, obesity, diabetes) regulates myelopoiesis, leukocyte trafficking to the brain, and behavior through some conserved mechanisms. The McKim lab aims to address important biomedical questions from a uniquely integrative, multidisciplinary approach.
Wednesday, October 23, 2019 at 12:00 PM
2506 Veterinary Medicine Basic Sciences Building
2001 South Lincoln Avenue, Urbana
For more information contact the Department of Pathobiology at 217-333-2449, email firstname.lastname@example.org.