BIOE Seminar Series: Department Chair & Dwight C. and Hildagarde E. Baum Professor Yingxiao Wang
- Sponsor
- Department of Bioengineering
- Speaker
- Department Chair Dwight C. & Hildagarde E. Baum Professor, Alfred E. Mann Department of Biomedical Engineering, Professor, Molecular Microbiology & Immunology, Viterbi School of Engineering, University of Southern California
- Views
- 47
- Originating Calendar
- Bioengineering calendar
Ultrasound Remote Control of Gene and Cell Therapy for Solid Tumors
Abstract: Ultrasound sonogenetics enables non-invasive, deep-tissue control of genetics and cellular functions by translating focused ultrasound signals into genetic and epigenetic responses. In this talk, I will present our lab’s development of ultrasound-responsive gene circuits to remotely guide CAR T cell immunotherapy against solid tumors and to achieve spatiotemporally precise genome and epigenome editing for disease treatment. This versatile platform offers unprecedented control over cell-based therapies and opens new directions for programmable medicine. I will highlight its potential in applications ranging from cancer immunotherapy to regenerative medicine and epigenetic reprogramming.
Biography: Dr. Wang obtained his bachelor’s and master’s degrees in Mechanics and Fluid Mechanics from Peking University, Beijing, P.R. China, in 1992 and 1996, respectively. He received his Ph.D. degree in Bioengineering from the University of California, San Diego Jacobs School of Engineering in 2002 and continued his postdoctoral work at UC San Diego working under Bioengineering Professor Shu Chien and Professor Roger Y. Tsien in the Department of Pharmacology. He is current the department chair and Dwight C. and Hildagarde E. Baum Chair professor in the department of Biomedical Engineering at USC and a fellow of American Institute of Medical and Biological Engineering (AIMBE), International Academy of Medical and Biological Engineering (IAMBE), and Biomedical Engineering Society (BMES). Before joining the USC in 2023, he was a faculty of Bioengineering at the University of Illinois, Urbana-Champaign (UIUC), and University of California, San Diego (UCSD). Dr. Wang is the recipient of the Wallace H. Coulter Early Career Award (both Phase I and Phase II), the National Science Foundation CAREER Award, and National Institutes of Health Independent Scientist Award. His research is on cellular and molecular engineering for live cell imaging and controllable cell-based therapy.